Authors: Hedrih, Anđelka 
Banić, Milan
Title: The effect of friction and impact angle on the spermatozoa-oocyte local contact dynamics
Journal: Journal of Theoretical Biology
Volume: 393
First page: 32
Last page: 42
Issue Date: 21-Mar-2016
Rank: M21
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2015.12.031
Although a large proportion of biomolecules involved in spermatozoa-oocyte interaction has been discovered so far, many details of fertilization mechanism remain unknown. Both biochemical and biomechanical components exist in the fertilization process. Mammalian sperm evolved a ZP (zona pelucida) thrust reduction penetration strategy probably in response to the ZP resilient elasticity.Using a biomechanical approach and FEM analysis, local contact stress, ZP deformations during impact and attempt of sperm head penetration relative to different sperm impact angles (SIA) were studied. The sperm-oocyte contact was defined as non-linear frictional contact. A transient structural analysis at 37 °C revealed that, from the mechanical standpoint there are SIA that are more favorable for possible ZP penetration due to larger equivalent stress of ZP. An "slip-stick" resembling effect was identified for almost all examined SIA. The sperm head-ZP contact area increases as SIA decreases. Favorable ZP-stress state for sperm penetration regarding SIA are discussed.
Keywords: Biomechanics | Finite element method | Local strain | Sperm impact angle | Zona pellucida
Publisher: Elsevier
Project: Dynamics of hybrid systems with complex structures. Mechanics of materials. 

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