DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hedrih, Anđelka | en |
dc.contributor.author | Banić, Milan | en |
dc.date.accessioned | 2020-04-27T10:55:11Z | - |
dc.date.available | 2020-04-27T10:55:11Z | - |
dc.date.issued | 2016-03-21 | en |
dc.identifier.issn | 0022-5193 | en |
dc.identifier.uri | http://researchrepository.mi.sanu.ac.rs/handle/123456789/844 | - |
dc.description.abstract | Although a large proportion of biomolecules involved in spermatozoa-oocyte interaction has been discovered so far, many details of fertilization mechanism remain unknown. Both biochemical and biomechanical components exist in the fertilization process. Mammalian sperm evolved a ZP (zona pelucida) thrust reduction penetration strategy probably in response to the ZP resilient elasticity.Using a biomechanical approach and FEM analysis, local contact stress, ZP deformations during impact and attempt of sperm head penetration relative to different sperm impact angles (SIA) were studied. The sperm-oocyte contact was defined as non-linear frictional contact. A transient structural analysis at 37 °C revealed that, from the mechanical standpoint there are SIA that are more favorable for possible ZP penetration due to larger equivalent stress of ZP. An "slip-stick" resembling effect was identified for almost all examined SIA. The sperm head-ZP contact area increases as SIA decreases. Favorable ZP-stress state for sperm penetration regarding SIA are discussed. | en |
dc.publisher | Elsevier | - |
dc.relation | Dynamics of hybrid systems with complex structures. Mechanics of materials. | - |
dc.relation.ispartof | Journal of Theoretical Biology | en |
dc.subject | Biomechanics | Finite element method | Local strain | Sperm impact angle | Zona pellucida | en |
dc.title | The effect of friction and impact angle on the spermatozoa-oocyte local contact dynamics | en |
dc.type | Article | en |
dc.identifier.doi | 10.1016/j.jtbi.2015.12.031 | en |
dc.identifier.pmid | 26780648 | en |
dc.identifier.scopus | 2-s2.0-84955074397 | en |
dc.relation.firstpage | 32 | en |
dc.relation.lastpage | 42 | en |
dc.relation.volume | 393 | en |
dc.description.rank | M21 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
crisitem.project.projectURL | http://www.mi.sanu.ac.rs/novi_sajt/research/projects/174001e.php | - |
crisitem.project.openAire | info:eu-repo/grantAgreement/NWO/null/2300174001 | - |
crisitem.author.orcid | 0000-0001-7598-900X | - |
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