DC FieldValueLanguage
dc.contributor.authorHedrih, Anđelkaen
dc.contributor.authorBanić, Milanen
dc.date.accessioned2020-04-27T10:55:11Z-
dc.date.available2020-04-27T10:55:11Z-
dc.date.issued2016-03-21en
dc.identifier.issn0022-5193en
dc.identifier.urihttp://researchrepository.mi.sanu.ac.rs/handle/123456789/844-
dc.description.abstractAlthough a large proportion of biomolecules involved in spermatozoa-oocyte interaction has been discovered so far, many details of fertilization mechanism remain unknown. Both biochemical and biomechanical components exist in the fertilization process. Mammalian sperm evolved a ZP (zona pelucida) thrust reduction penetration strategy probably in response to the ZP resilient elasticity.Using a biomechanical approach and FEM analysis, local contact stress, ZP deformations during impact and attempt of sperm head penetration relative to different sperm impact angles (SIA) were studied. The sperm-oocyte contact was defined as non-linear frictional contact. A transient structural analysis at 37 °C revealed that, from the mechanical standpoint there are SIA that are more favorable for possible ZP penetration due to larger equivalent stress of ZP. An "slip-stick" resembling effect was identified for almost all examined SIA. The sperm head-ZP contact area increases as SIA decreases. Favorable ZP-stress state for sperm penetration regarding SIA are discussed.en
dc.publisherElsevier-
dc.relationDynamics of hybrid systems with complex structures. Mechanics of materials.-
dc.relation.ispartofJournal of Theoretical Biologyen
dc.subjectBiomechanics | Finite element method | Local strain | Sperm impact angle | Zona pellucidaen
dc.titleThe effect of friction and impact angle on the spermatozoa-oocyte local contact dynamicsen
dc.typeArticleen
dc.identifier.doi10.1016/j.jtbi.2015.12.031en
dc.identifier.pmid26780648en
dc.identifier.scopus2-s2.0-84955074397en
dc.relation.firstpage32en
dc.relation.lastpage42en
dc.relation.volume393en
dc.description.rankM21-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
crisitem.author.orcid0000-0001-7598-900X-
crisitem.project.projectURLhttp://www.mi.sanu.ac.rs/novi_sajt/research/projects/174001e.php-
crisitem.project.openAireinfo:eu-repo/grantAgreement/NWO/null/2300174001-
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