Authors: Dragović, Branko
Dragovich, Alexandra
Title: p-adic modelling of the genome and the genetic code
Journal: Computer Journal
Volume: 53
Issue: 4
First page: 432
Last page: 442
Issue Date: 1-May-2010
ISSN: 00104620
DOI: 10.1093/comjnl/bxm083
This paper presents the foundations of p-adic modelling in genomics. Considering nucleotides, codons, DNA and RNA sequences, amino acids and proteins as information systems, we have formulated the corresponding p-adic formalisms for their investigations. Each of these systems has its characteristic prime number used for construction of the related information space. Relevance of this approach is illustrated by some examples. In particular, it is shown that degeneration of the genetic code is a p-adic phenomenon. We have also put a forward a hypothesis on the evolution of the genetic code assuming that primitive code was based on single nucleotides and chronologically first four amino acids. This formalism of p-adic genomic information systems can be implemented in computer programs and applied to various concrete cases. © The Author 2007. Published by Oxford University Press on behalf of The British Computer Society. All rights reserved.
Keywords: Evolution of the genetic code | Genetic code | Genome | P-adic genomic space | P-adic modelling

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