Authors: Kapunac, S.
Malkov, S.
Beljanski, M.
Pavlović Lažetić, G.
Stojanović, Biljana 
Maljković, M.
Veljković, A.
Mitić, N.
Affiliations: Computer Science 
Mathematical Institute of the Serbian Academy of Sciences and Arts 
Title: Analysis of nucleotide sequence repeats in coronaviruses
First page: 80
Related Publication(s): Book of Abstracts : 4th Belgrade BioInformatics Conference - BelBI2023
Conference: 4th Belgrade BioInformatics Conference - BelBI2023. 19-23 June 2023 Belgrade, Serbia
Issue Date: 2023
Rank: M34
ISBN: 978-86-82679-14-1
Repeats in nucleotide sequences are connected with various genome
characteristics. RNA secondary structures are related to repeats at the
primary structure level. Four different types of nucleotide repeats may be
identified: direct non-complementary, direct complementary, inverse
non-complementary and inverse complementary. Reverse complementary tandem
repeats, for example, may form hairpin secondary structures, while reverse
non-complementary may be recognized by proteins. On the other side, direct
complementary and/or non-complementary repeats may be reflected in protein
sequence repeats, if found in the same reading frame, within the
protein-coding sequence.
Here we analyzed (determined and compared) all four types of nucleotide
repeats in referent sequences of SARS-CoV-1, SARS-CoV-2 and MERS-COV
viruses. In addition to the complete repeat set, we analyze different
repeat subsets: repeats with the left component within the 5′ end, repeats
with the right component within the 3′ end, and repeats with at least one
component within the surface glycoprotein coding sequence.
We found significant differences in repeat sets corresponding to analyzed
sequences in all analyzed repeat sets. In this moment we can only
speculate what are the real consequences of the discovered differences.
Keywords: SARS-COV | MERS-COV | SARS-COV-2 | nucleotide repeats
Publisher: Institute of Molecular Genetics and Genetic Engineering, University of Belgrade

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