Authors: Dragović, Branko
Mišić, Nataša
Title: p-Adic hierarchical properties of the genetic code
Journal: BioSystems
Volume: 185
Issue Date: 1-Nov-2019
ISSN: 03032647
DOI: 10.1016/j.biosystems.2019.104017
URL: https://api.elsevier.com/content/abstract/scopus_id/85071080070
Abstract: 
© 2019 Elsevier B.V. In this article, we consider p-adic modeling of the standard genetic code and the vertebrate mitochondrial one. To this end, we use 5-adic and 2-adic distance as a mathematical tool to describe closeness (nearness, similarity) between codons as elements of a bioinformation space. Codons which are simultaneously at the smallest 5-adic and 2-adic distance code the same (or similar) amino acid or stop signal. The set of codons is presented as an ultrametric tree as well as a fractal and p-adic network. It is shown that genetic code can be treated as sequential translation between genetic languages. This p-adic approach gives possibility to be applied to sequences of nucleotides of an arbitrary finite length. We present an overview of published and some new results on various p-adic properties of the genetic code.
Keywords: Amino acids | Bioinformation | Genetic code | Genetic language | p-Adic distance | p-Adic network | Ultrametric codon tree

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