Authors: Hedrih, Anđelka 
Banić, Milan
Title: The effect of friction and impact angle on the spermatozoa-oocyte local contact dynamics
Journal: Journal of Theoretical Biology
Volume: 393
First page: 32
Last page: 42
Issue Date: 21-Mar-2016
Rank: M21
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2015.12.031
Abstract: 
Although a large proportion of biomolecules involved in spermatozoa-oocyte interaction has been discovered so far, many details of fertilization mechanism remain unknown. Both biochemical and biomechanical components exist in the fertilization process. Mammalian sperm evolved a ZP (zona pelucida) thrust reduction penetration strategy probably in response to the ZP resilient elasticity.Using a biomechanical approach and FEM analysis, local contact stress, ZP deformations during impact and attempt of sperm head penetration relative to different sperm impact angles (SIA) were studied. The sperm-oocyte contact was defined as non-linear frictional contact. A transient structural analysis at 37 °C revealed that, from the mechanical standpoint there are SIA that are more favorable for possible ZP penetration due to larger equivalent stress of ZP. An "slip-stick" resembling effect was identified for almost all examined SIA. The sperm head-ZP contact area increases as SIA decreases. Favorable ZP-stress state for sperm penetration regarding SIA are discussed.
Keywords: Biomechanics | Finite element method | Local strain | Sperm impact angle | Zona pellucida
Publisher: Elsevier
Project: Dynamics of hybrid systems with complex structures. Mechanics of materials. 

Show full item record

SCOPUSTM   
Citations

4
checked on Sep 16, 2022

Page view(s)

25
checked on Sep 28, 2022

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.