|Title:||The effect of friction and impact angle on the spermatozoa-oocyte local contact dynamics||Journal:||Journal of Theoretical Biology||Volume:||393||First page:||32||Last page:||42||Issue Date:||21-Mar-2016||Rank:||M21||ISSN:||0022-5193||DOI:||10.1016/j.jtbi.2015.12.031||Abstract:||
Although a large proportion of biomolecules involved in spermatozoa-oocyte interaction has been discovered so far, many details of fertilization mechanism remain unknown. Both biochemical and biomechanical components exist in the fertilization process. Mammalian sperm evolved a ZP (zona pelucida) thrust reduction penetration strategy probably in response to the ZP resilient elasticity.Using a biomechanical approach and FEM analysis, local contact stress, ZP deformations during impact and attempt of sperm head penetration relative to different sperm impact angles (SIA) were studied. The sperm-oocyte contact was defined as non-linear frictional contact. A transient structural analysis at 37 °C revealed that, from the mechanical standpoint there are SIA that are more favorable for possible ZP penetration due to larger equivalent stress of ZP. An "slip-stick" resembling effect was identified for almost all examined SIA. The sperm head-ZP contact area increases as SIA decreases. Favorable ZP-stress state for sperm penetration regarding SIA are discussed.
|Keywords:||Biomechanics | Finite element method | Local strain | Sperm impact angle | Zona pellucida||Publisher:||Elsevier||Project:||Dynamics of hybrid systems with complex structures. Mechanics of materials.|
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